This information is found on M.D. Anderson’s website.

“Like most cancer, the prognosis depends on the stage of disease at the time of diagnosis. In one study of women with NEC of the cervix, 71% of patients were diagnosed with early stage disease (stage I-IIA), 24% were diagnosed with locally advanced disease (stage IIB-IVA), and 4% with diagnosed with distant metastatic disease (stage IVB) [9].

When looking at patients diagnosed at all stages, five year survival for NEC of the cervix is worse than that for other more common types of cervical cancer (36 vs 60-70%) [15]. In the same study mentioned above, 5-year survival was 37% for those with I-IIA disease versus 9% for those with more advanced disease. In another series, survival for stage I was 42%, stage II 19%, stage III 10% and stage IV 23% [7].

It appears that prognosis for small cell neuroendocrine carcinoma originating from the cervix is better than when originating in the lung. As noted above, while the five year survival for patients with early stage NEC of the cervix ranges from 19- 42%, the survival for limited stage lung cancer is about 10%. Similarly, the survival for those with extensive stage disease of the cervix is about 10-23%, while the comparable survival rates for disease starting in the lung is 1-2% [16].”

7. McCusker, M.E., et al., Endocrine tumors of the uterine cervix: incidence, demographics, and survival with comparison to squamous cell carcinoma. Gynecol Oncol, 2003. 88(3): p. 333-9.

9. Cohen, J.G., et al., Small cell carcinoma of the cervix: treatment and survival outcomes of 188 patients. Am J Obstet Gynecol, 2010. 203(4): p. 347 e1-6.

15. Chen, J., O.K. Macdonald, and D.K. Gaffney, Incidence, mortality, and prognostic factors of small cell carcinoma of the cervix. Obstet Gynecol, 2008. 111(6): P. 1394-402.

16. Gaspar, L.E., et at., Limited-stage small-cell lunch cancer (stages I-III): observations from the National Cancer Data Base. Clin Lung Cancer, 2005. 6(6): p. 355-60.

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